![]() Ion 316 chips were utilised with the Ion Torrent semi-conductor platform Personal Genome Machine (PGM) to perform tandem sequencing of mitochondrial genomes from the core pedigree (n = 315) of the Norfolk Island Health Study. We summarise an efficient and cost-effective NGS approach for mitochondrial genomic DNA in humans using the Ion Torrent platform, and further discuss our bioinformatics pipeline for streamlined variant calling. ![]() The implementation and popularity of next generation sequencing (NGS) has led to the development of various rapid whole mitochondrial genome sequencing techniques. Griffiths, Conceptualization, Project administration, Resources, Supervision, Writing – review & editing 1, * Haupt, Conceptualization, Investigation, Methodology, Project administration, Supervision, Writing – review & editing, 1 and L. Lea, Formal analysis, Supervision, Visualization, Writing – review & editing, 1 L. Allcock, Methodology, Writing – review & editing, 3 R. Sutherland, Conceptualization, Methodology, Supervision, Writing – review & editing, 1 R. Connell, Methodology, Writing – review & editing, 1 H. Eccles, Formal analysis, Writing – review & editing, 1 J. Benton, Formal analysis, Methodology, Visualization, Writing – review & editing, 1, ¤b D. Stuart, Formal analysis, Investigation, Methodology, Validation, Writing – original draft, 1, ¤a M. ![]() Albury, Investigation, Methodology, Writing – original draft, # 1 S. Harvey, Conceptualization, Formal analysis, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing, # 1, 2 C. ![]()
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